Multiple organ dysfunction syndrome in children with sepsis: role of genetic factors.
نویسندگان
چکیده
This review summarizes current knowledge on the impact of genetic markers on susceptibility, severity, and outcome of acute inflammatory disorders in children, with a special focus on systemic infections. A 14-year-old child with Neisseria meningitides bacteremia, complicated by septic shock and multiple organ dysfunction, is discussed as an exemplary case, and linked to the application of genetic epidemiology and the study of common disorders in children. The current pertinent literature is comprehensively reviewed and limitations and future directions are discussed.
منابع مشابه
Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis
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ورودعنوان ژورنال:
- Seminars in nephrology
دوره 28 5 شماره
صفحات -
تاریخ انتشار 2008